ANSWERS TO T3

IDENTIFICATION
1. Triiodothyronine
2 -3. 1 monoiodothyronine
1 diiodothyronine
4. Thyroid Gland
5. 0.8 - 1.1 ug/dL
6. Hyperthyroidism
7. Hypothyroidism
8 -10. Direct Equilibrium Dialysis or Infiltration
Determination of T3 by Radioimmunoassay (T3(RIA)

Determination of T3 Uptake by Radioassay

CASE ANALYSIS

The probable diagnosis is HYPERTHYROIDISM AND ANEMIA , and additional test like TSH can help in the diagnosis of the disease.
DECREASED TSH is indicative of hyperthyroidism with increased T3 and T4 level.
we could PERFORM STIMULATION TEST IF TSH IS UNDETECTABLE.

Hyperthyroidism can be manage and treated through ANTI-THRYROID DRUGS, RADIOACTIVE IODINE TREATMENT, and SURGICAL REMOVAL

Click link for additional information:
http://www.webmd.com/a-to-z-guides/hyperthyroidism-topic-overview
http://www.endocrineweb.com/hyper4.html

THINK for T3

Thinking hard or hardly thinking? ;p

IDENTIFICATION

1. Transcribe T3
2-3. Molecules of T3
4. Produce from what organ?
5. Normal Value
6. Disease associated with increased T3
7. Disease associated with decrease T3
8-10. 3 Methods For T3


CASE ANALYSIS

Archie, a 4 year old boy, is experiencing fever and nausea with vomiting, he has short structure and still unable and walk and speak. He was tested for CBC which resulted to decreased in RCC. His T3 values is increased while his T4 is within normal range.


What is the possible diagnosis?
What are the possible test to confirm diagnosis?
What is the probable result of TSH based from the diagnosis?
What if TSH value is undetectable?
What are the availbale treatment for the disease?

Triiodothyronine

Triiodothyronine, with the chemical structure of 3,5,3'-L-triiodothyronine, well known as T3 because of it's difficulty to pronounce is one of the main Thyroid Hormone produced from the Thyroid gland and controlled by the TSH form the anterior pituitary gland. T4 with T3 are the most important hormone that affects metabolic rates. they help regulates the metabolic processes which are essential for a normal growth and development of our body and the maturation of our brain cells.
t3 is 3 to 5 times more potent biological system thab t4 because one third of all t4 are converted to t3 during the course of it's metabolism.

Functions

• increased oxygen consumption


• growth


• development


• sexual maturation


• stimulation of heart rate and heart contraction


• protein synthesis


• carbohydrate metabolism


• cholesterol and TAG synthesis and degradation

IDEAL SPECIMEN: serum; plasma with EDTA or heparin may also be used

METHODS

• Direct Equilibrium Dialysis or Infiltration


• Determination of T3 by Radioimmunoassay (T3(RIA)


• Determination of T3 Uptake by Radioassay

Normal Values: 0.8 - 1.1 ug/dL

Clinical Significance:

• Primary Hypothyroidism - has damage in the thyroid gland and insufficient in hormone synthesis. Confirmation of the disease is the results where T3 and T4 decrease; TSH increase.


• Congenital Hypothyroidism - due to absence of thyroid gland or defects on thyroid hormone synthesis.


• Secondary Hypothyroidism - due to pitiutary or hypothalamic disease;

• Hyperthyroidism - can be caused by diffused toxic goiter, damage to the thyroid gland. T3 is elevated early than T4.

REFERENCES

Tietz Textbook of Clinical Chemistry Second Edition by Karl A. Burtis and Edward R. Ashwood

Fundamentals of Clinical Chemistry Third Edition by Norbert W. Tietz

Welcome

Hi, I'm Kelly Shaye, welcome to my blog.